MCAD deficiency affects one out of 10 000 newborns.

Medium-Chain Acyl-CoA Dehydrogenase (MCADD)

MCADD is a congenital fatty acid oxidation disorder. This disease becomes apparent when the body has to access fat reserves during prolonged periods of fasting, and causes vomiting, diarrhoea and fever, for example, as a result of viral infections experienced frequently throughout childhood. The effects are drowsiness, nausea, seizures and coma. If undiagnosed, the first onset frequently leads to death and is reminiscent of “sudden infant death”.

If appropriate measures are taken – avoidance of long periods of fasting and providing a sufficient intake of carbohydrates, especially during infections and fever - the prognosis is excellent.

MCADD affects one in 10,000 newborns.

 

 
Therapy:
  • Low-fat and high-carb foods.
  • Long-term care should be given in collaboration with a specialized metabolic centre, which can carry out the regularly required clinical tests and laboratory controls.
     

 

 
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